Vegetation are already historically a source of analgesic alkaloids, Even though their pharmacological characterization is usually restricted. Among these normal analgesic molecules, conolidine, present in the bark in the tropical flowering shrub Tabernaemontana divaricata Conolidine belongs

Regardless of the questionable efficiency of opioids in running CNCP and their high rates of Negative effects, the absence of available different prescription drugs and their medical limits and slower onset of action has resulted in an overreliance on opioids. Persistent ache is tough to treat.